The role of extracellular vesicles in parasite-host interaction
Justyna Gatkowska 1, Henryka Długońska 1 1 - Zakład Immunoparazytologii, Katedra Immunologii i Biologii Infekcyjnej, Wydział Biologii i Ochrony Środowiska, Uniwersytet Łódzki Postepy Hig Med Dosw 2016; 70 951-958 ICID: 1218189 Article type: Review article
Extracellular vesicles (EVs), initially considered cell debris, were soon proved to be an essential tool of intercellular communication enabling the exchange of information without direct contact of the cells. At present EVs are the subject of extensive research due to their universal presence in single- and multi-cell organisms, regardless of their systematic position, and their substantial role in cell-to-cell communication. EVs seem to be released by both prokaryotic and eukaryotic cells under natural (in vivo) and laboratory (in vitro) conditions. Even purified fractions of isolated EVs comprise various membrane-derived structures. However, EVs can be classified into general groups based primarily on their size and origin. EVs may carry various materials, and ongoing research investigations give new insight into their potenti participation in critical biological processes, e.g. carcinogenesis. This paper presents current knowledge on the EVs’ involvement in host–parasite interactions including the invasion process, the maintenance of the parasite infection and modulation of the host immune response to parasite antigenic stimulation, as well as perspectives of the potential use of EVs as immunoprophylactic and diagnostic tools for controlling parasite infections. The most numerous literature data concern protozoan parasites, especially those of the greatest medical and social importance worldwide. However, available information about the EVs’ contribution to helminth invasion has also been included.
DOI: 10.5604/17322693.1218189 PMID 27668647 - kliknij tu by zobaczyć artykuł w bazie danych PubMed