Związek między podstawowymi parametrami stresu zapalnego i zaburzeniami metabolicznymi
Sylwia Płaczkowska 1, Lilla Pawlik-Sobecka 1, Izabela Kokot 1, Dariusz Sowiński 2, Małgorzata Wrzosek 3, Agnieszka Piwowar 4 1 - Department of Professional Training in Clinical Chemistry, Faculty of Pharmacy, Wroclaw Medical University, Poland 2 - The Regional Specialist Outpatient Clinic, Wroclaw, Poland 3 - Department of Biochemistry and Clinical Chemistry, Faculty of Pharmacy, Warsaw Medical University, Poland 4 - Department of Pharmaceutical Biochemistry, Faculty of Pharmacy, Wroclaw Medical University, Poland Postepy Hig Med Dosw 2014; 68 1374-1382 ICID: 1130083 Article type: Original article
Background: Inflammation is involved in initiation and progression of diabetic complications related
to cell damage of tissues, especially endothelial cells, and deepening of metabolic disturbances. This
study was conducted in order to assess potential associations between basic laboratory parameters
of inflammation and common metabolic factors such as glycated hemoglobin and C-reactive protein.
Materials and methods: The studied group consisted of 95 patients with diabetes mellitus type 2
and 77 subjects without signs of disturbances in glucose metabolism, aged between 40 and 74 years.
Fasting plasma glucose, glycated hemoglobin, complete blood count and high-sensitivity C-reactive
protein concentration in blood were determined. Also blood pressure as well as weight and height
measurements were taken to calculate BMI.
Results: Fasting plasma glucose and glycated hemoglobin concentrations, total leukocyte count and
granulocytes were significantly higher in diabetics. Significant correlations between both glycated
hemoglobin and BMI and C-reactive protein concentration were noted. However, after adjusting
for age and gender, leucocyte count was independently related to BMI and glycated hemoglobin,
while C-reactive protein concentration was dependent on gender and BMI.
Conclusion: Glycated hemoglobin as a marker of long-term glycemic control and BMI as an indicator
of adipose tissue accumulation are significantly related to white blood cell count and C-reactive
protein concentration, even when values of these parameters are in the normal range. This
is consistent with the hypothesis that chronic activation of the immune system plays a role in the
pathogenesis and progression of type 2 diabetes.