Salmonellozy RAS jako ważny problem epidemiologiczny

Aleksandra Pawlak 1
1 - Zakład Mikrobiologii, Instytut Genetyki i Mikrobiologii, Uniwersytet Wrocławski
Postepy Hig Med Dosw
2014; 68 1335-1342
ICID: 1129123
Article type: Review article
Salmonellosis is a serious health problem throughout the world. It is the most common form of food poisoning. One of the reservoirs of Salmonella are reptiles, which are increasingly kept as pets. Most reptiles are asymptomatic carriers of Salmonella. These strains, isolated from reptiles, can cause serious infections, especially in infants, young children and people with immunodeficiencies. The disease called reptile-associated salmonellosis (RAS) may manifest with bloody diarrhea, meningitis, and arthritis, and consequently can cause bacteremia and sepsis. Among the strains described in the literature, Salmonella strains possessing the O48 antigen are an important group. Lipopolysaccharide (LPS) of Salmonella O48 contains sialic acid (NeuAc) in an O-specific-chain. LPS containing NeuAc exhibits antigenic similarity to antigens found in the human body, including blood serum, and therefore is correlated with the occurrence of the dangerous phenomenon of molecular mimicry. Bacteria containing NeuAc in their outer structures can evade the immunological response of the host, which significantly increases their virulence. Most data about RAS come from the USA, but in recent years cases from European countries are more frequent in the literature. Unfortunately, the occurrence of RAS in Poland has not been monitored so far. There is also no campaign to inform the public about the health risks connected with contact of people with reptiles.
DOI: 10.5604/17322693.1129123
PMID 25404622 - kliknij tu by zobaczyć artykuł w bazie danych PubMed

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