Michał Chojnacki 1, Adam Kwapisz 2, Marek Synder 2, Janusz Szemraj 1 1 - Zakład Biochemii Medycznej, Uniwersytet Medyczny w Łodzi 2 - Klinika Ortopedii i Ortopedii Dziecięcej, Uniwersytet Medyczny w Łodzi Postepy Hig Med Dosw 2014; 68 640-652 ICID: 1103551 Article type: Review article
Osteoarthritis is an incurable joint disease manifesting itself with gradually progressing degenerative changes, leading to premature motor disability. These changes mainly occur owing to an imbalance between the processes of degeneration and regeneration of articular cartilage structures. Until now many risk factors favoring the development of degenerative joint disease have been identified. These include age, weight, previously sustained traumas to joints, sports, sex and genetic predisposition. The latest scientific reports confirm that the pathogenesis of changes in osteoarthritic joints is complex and occurs on many levels. Enzymes belonging to the metalloproteinases family are mainly responsible for the degeneration of articular cartilage. Their activity is regulated by numerous pro-inflammatory cytokines, transcription factors and miRNA. A thorough analysis of all processes occurring in the afflicted joints needs to be carried out before effective therapeutic strategies can be developed.
DOI: 10.5604/17322693.1103551 PMID 24864114 - kliknij tu by zobaczyć artykuł w bazie danych PubMed